This list includes two on The 50 Best Bars and two on Europe's 50 Best.

Locale pours inside Palazzo Concini, a palace whose bones date to the 1200s and whose basement arches may be Roman, the 'Labo-ttega' bar lab is tucked into that medieval underbelly. Bar manager Fabio Fanni's program is low-waste classics-with-a-twist built on seasonal produce and modern technique; the 2026 menu names its drinks after Italian hand gestures. No. 33 on The 50 Best Bars 2026 (No. 22 in 2025) and No.21 in Europe for 2026. No bar reservations, walk in.

Gucci's all-day café-bar on Piazza della Signoria opened in 2022 in a space once occupied by a florist, the interior still nods to it, with head mixologist Martina Bonci building inventive, visually striking drinks with and without alcohol. Part of the Gucci Osteria da Massimo Bottura family, it placed No.29 on Europe's 50 Best Bars 2026. Order the Mémoire di Negroni (€21). It sits at No. 91 on The 50 Best Bars 51-100 list in 2026, after No. 99 on the 51-100 list in 2025.

Founded at the end of 2019 and grown within three years into four venues, Florence, Rome, Venice and Villa Cora, Santa Cocktail Club is Giulio Fratini's soft-lit room on Piazza Santa Maria Novella, with bar manager Simone Covan running a laboratory-style drinks program and executive chef Massimo Scervino's kitchen blending tradition and experimentation.

Founded in 1896 as Florence's house of household wares and revived on the original Via dei Ginori premises in 2015, La Ménagère is a concept space, restaurant, bistrot, flower boutique and live-music room with grand piano, where the day runs from coffee and baked goods to evening cocktails designed by Luca Cinalli, paired with the chef's creative tapas.
These are the cocktail bars specifically. The full Florence guide ranks the best bars of every style, and the directory lists all 18 with a map and filters.