Brussels cocktail bars range from Prohibition-era hideaways to a steampunk curiosity cabinet. The best cocktail bars in Brussels include Chemistry & Botanic's near the Grand Place, which builds seasonal drinks on homemade syrups, infusions and local botanicals, and La Pharmacie Anglaise on Coudenberg, whose menu credits each creation to a named bartender. In Saint-Gilles, The Modern Alchemist has poured from more than 150 rums since 2018. Confessions in Ixelles comes from the team behind New York's Dear Irving and serves punch in teapots, and Plumette, an art deco speakeasy in the Marolles, has a terrace facing the Palais de Justice. Most guests walk in at The Modern Alchemist, but groups should book. These are the six we would start with.

Chemistry & Botanic's is an intimate cocktail bar a short walk from the Grand Place and Central Station, built on the idea of science meeting the plant world. The mixologists follow the seasons, working with selected spirits, homemade syrups, infusions and local botanicals, and make drinks with or without alcohol. The bar also hosts cocktail workshops and can be booked for private events, and dogs are welcome.

La Pharmacie Anglaise is a cocktail bar on Coudenberg that presents itself as a place of cocktails and curiosity. The wood panelled room is lined with curiosity cabinets and apothecary jars, and a giraffe stands among the armchairs. The menu lists house creations credited to individual bartenders, barrel aged drinks and a dry Martini made to order, and entry is for guests aged 18 and over.

The Modern Alchemist is a neighborhood cocktail bar in Saint-Gilles that opened in December 2018 in a renovated old café. The drinks focus on rum, with more than 150 references, and seasonal house creations, and the bar also sells bottled cocktails. Christopher runs the bar today with Marie and Cedric, and walk-ins are welcome.
Confessions is a lounge cocktail bar on Parvis de la Trinité in Ixelles with the mood of a New York speakeasy. It comes from the people behind Dear Irving and Raines Law Room, and serves cocktails built on fresh ingredients and premium spirits alongside small bites. The room pairs a curated music selection with artistic decor, and the bar also runs cocktail classes and private parties.
Life is Beautiful is a cozy cocktail bar on Rue Antoine Dansaert with a boutique selling spirits, bitters, bottled cocktails and bar tools. The menu changes often and runs from classics to signature creations that draw on stories and cultures. The team also runs cocktail workshops and private events, and has a sister bar, Fox Den, in Schaerbeek.
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These are the cocktail bars specifically. The full Brussels guide ranks the best bars of every style, and the directory lists all 9 with a map and filters.