Seven cocktail bars in Guadalajara, including one on The 50 Best Bars and two on North America's 50 Best.

El Gallo Altanero is an agave bar in Guadalajara's Colonia Americana, entered through a cafe, with thirteen seats, rooster artwork and a backlit stained-glass agave window. The menu changes regularly and rebuilds classics with tequila, raicilla and mezcal, led by its Jalisco Old Fashioned.

A bar and kitchen in a converted garage in Colonia Americana, named after the Roman arts patron Gaius Cilnius Maecenas. It is led by José Luis Hinostroza with head bartender Arturo Santos and draws on art, culture and craft for its drinks program. The team makes its own liqueurs from cane alcohol infused with botanicals and fresh fruit, works with the local distillery Satvrnal, and produces fortified wines with Discográfica winery. It currently stands at No. 18 on North America's 50 Best Bars 2026.
Bar Fandango is a cocktail bar on Calle Nicolás Romero in Colonia Americana, Guadalajara, and its Instagram bio sums it up in four words: "Es lo que es." The program is built on the classics, and the martini, served very cold, sits at its center. Monday is martini night, which the bar bills as a club for martini lovers and lovers in general, and its line is that the classics never die. The club idea stretches to themed evenings, such as a Negroni and pasta night in September 2026. In 2026, Tales of the Cocktail named Bar Fandango one of its Spirited Awards Latin America and Caribbean regional top 10 honorees for Best New International Cocktail Bar.
De La O is a cantina on Calle Argentina in Colonia Americana, named for the revolutionary Genovevo de la O. Its cocktail list works local ferments such as tepache and pulque into agave and rum drinks, with a playful nod to tiki. The bar is built around daytime drinking, opening from early afternoon. It takes no reservations and welcomes pets.
Farmacia Rita Pérez is a pharmacy-themed cantina on Calle Colonias in Colonia Americana that describes its offer as Mexican medicine. The cocktail list runs from house classics to botica and yerbero drinks built on herbs, backed by mezcal, tequila, raicilla, bacanora, sotol and pox. Aguachiles, tortas ahogadas and tacos come from the kitchen, and the room is 18 and over after 7pm.
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Guilty calls itself not your regular cocktail bar. It sits on the second floor at Morelos 1360 in Colonia Americana, where a blue light marks the way in. Reservations are taken by phone, and the bar runs until 3am on Fridays and Saturdays.
Pare de Sufrir, Spanish for 'end your suffering', is a mezcal bar on Calle Argentina in Colonia Americana, and it calls itself a cultural center for music, mezcal and traditional drinks. The shelves hold more than 70 varieties of mezcal, including several bottles of pechuga, a style made with chicken breast. Pedro Jiménez, who founded the bar, is also behind Mezonte, an organization of mezcal producers, and the documentary Viva Mezcal. Music is central to the place, with guest acts and nights such as karaoke, and the bar's own tagline sums up the rest: stop suffering, drink mezcal.
These are the cocktail bars specifically. The full Guadalajara guide ranks the best bars of every style, and the directory lists all 8 with a map and filters.