This list includes one on The 50 Best Bars and one Spirited Awards winner.

Alquimico opened in 2016 inside a colonial mansion in Cartagena's historic center, designed by the French architect Gaston Lelarge and spread across three floors: the Mansion bar, the Balcony for classics and the farm-inspired Terrace. The bar calls itself an ecosystem rather than simply a cocktail bar, and its From the Bar to the Farm project links it directly to producers and to its own farm in Filandia, Quindio. An in-house lab turns Colombian fruit and spices into wines and meads.
El Barón is a café and cocktail bar on Plaza San Pedro Claver, at Carrera 4 #31-7 in Cartagena's historic Old City. The rustic room is small and snug, and a terrace offers a spot for drinking outdoors. The list mixes classic cocktails with the bar's own creations, and mezcal features strongly: the Rosarito, one of the top sellers, combines it with cilantro, pineapple extract and bitters. There is also a daytime menu, food, an aperitivo hour and Cuban and Colombian cigars matched with spirits. Sustainability runs through the operation, with glass bottles reused, herbs from a rooftop garden and some cocktail proceeds going to environmental causes. It opens at 4 pm Monday to Thursday and at noon from Friday to Sunday. El Barón placed No. 66 on The World's 50 Best Bars 51-100 list in 2022.
Townhouse says it was the first hotel in the city to open its rooftop to the public, and describes the roof as a cocktail bar, an all-day diner and two little plunge pools, open from eight in the morning until midnight, with a reservation required for anyone not staying in the house. The menu is written around fresh, sustainable ingredients, to the point, the hotel says, of telling you which tree your mango came from. The Spirited Awards placed it in the international top ten for Best International Hotel Bar in 2020 and 2022.

Bar Lelarge is a cocktail bar inside Club Cartagena, the 1920s beaux-arts building at the heart of Four Seasons Hotel and Residences Cartagena on Calle de la Media Luna in Getsemaní. Created with Major Food Group, the candlelit room pairs a wine list with cocktails built on local, seasonal Colombian fruit and a light Cuban accent. Chef Mario Carbone's tapas are made for sharing, and the bar welcomes visitors as well as hotel guests.

El Coro Lounge Bar sits in the 400 year old Novices' Choir of the former convent that now houses Sofitel Legend Santa Clara, in Cartagena's historic center. The drinks take Cuban classics as a starting point, with mojitos, premium rums, house creations and mocktails, served with Caribbean sharing plates. Cuban son plays on Thursday evenings and Latin and Caribbean bands on Fridays and Saturdays.
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These are the cocktail bars specifically. The full Cartagena guide ranks the best bars of every style, and the directory lists all 7 with a map and filters.